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Genome Network Project
[Brochure]


Genome Network Project [Brochure]
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ゲノムネットワーク プラットフォーム

Genome Network Project
  Ministry of Education, Culture, Sports, Science and Technology
 
Purpose and Summary of the Project
 
   Once the decoding of the human genome was completed in 2003, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started the Genome Network Project in 2004.

   Genes are believed to operate by mutually adjusting each gene functions in order to exhibit biological phenomena rather than function independently.
   The aim of the Genome Network Project is to elucidate such complex interactions between human genomes - that is to say, the network of human genes. Once this human genome network has been revealed, we will be able to utilize the information for the further development of human life sciences and new treatments for diseases.

   To achieve this aim, the Project is carried out through collaboration between a number of organizations, each responsible for one of the following tasks: 1) investigating the network structure, 2) systematically summarizing findings and providing them to related research bodies, 3) developing new gene analysis technologies, 4) elucidating further biological phenomena by analyzing their networks, and 5) developing analytical technologies for the dynamic networks..

Figure 1

<Figure 1> Aim of the Genome Network Project

Project Structure
    The Genome Network Project is composed of five strategic research programs that are collaborating together. The first program is the “Analysis of Genome Functional Information” which intends to elucidate the genome network structure. The second is the “Establishment of Human Genome Network Platform” which is systematically organizing the research results and common data on genome information and providing them to appropriate research organizations. The third is the “Development of Genome Analysis Technologies for the Next Generation” which is carrying out studies into new methods and technologies for genome network analysis. The fourth is the “Analysis of Individual Biological Functions” whose aim is to elucidate Individual Biological functions and further utilize the genome network information. Last but not least, “Development of Analytical Technologies for Dynamic Network” will elucidate dynamic characteristics.

Figure 2

<Figure 2> Structure of the Genome Network Project

(1) Analysis of Genome Functional Information
     The major part of this research program, to be carried out by RIKEN (the Institute of Physical and Chemical Research), is concerned with exhaustive genome network analysis of genome functions, including human genome expression and interactions among biomolecules (e.g. proteins) that are relevant to such expression. Another activity within this research program is the organization of resources that can be shared among research organizations to enable the Project to progress efficiently including siRNA and cDNA resources. In order to integrate the overall analysis efforts, part of the data and test samples utilized in this research program will be supplied by the research bodies participating in the "Analysis of Individual Biological Functions". The research results from this program will then be provided to a wider array of research organizations through "Human Genome Network Platform", now being established by the National Institute of Genetics (NIG).
(2) Establishment of Human Genome Network Platform
     The research results obtained by the research programs, including "Analysis of Genome Functional Information", are being dynamically linked with existing genome information and transformed into an information platform that supports "Analysis of Individual Biological Functions" research, as described below. Ultimately, this platform will widely disseminate comprehensive research results from the Project to both academic and industrial circles.
(3) Development of Genome Analysis Technologies for the Next Generation
     This research program aims to develop new genome analysis methods and component technologies that will supersede those available today. Such new techniques and technologies can then be utilized by a variety of member research organizations in the Project, such as those involved with "Analysis of Genome Functional Information".
(4) Analysis of Individual Biological Functions
      This research program enables life science researchers working in their respective fields to develop various biological functions based on the data gained through the Project. The research results from this program are expected to contribute to the development of new treatments for diseases and the elucidation of biological functions.
(5)Development of Analytical Technologies for Dynamic Network
      This research program aims to develop technologies for elucidating the dynamic characteristics of genome networks, using as a foundation the static map of molecular interactions in transcriptional regulation that has already been constructed. To this end, researchers conducting systematic data acquisition will collaborate with researchers in mathematical science, system engineering and bioinformatics to conduct research on dynamic networks.

Project Research Promotion
    The Genome Network Project has been proceeding with a total of 38 research themes since 2004 until now, 2008. To promote this Project, a variety of groups are systematically organized under the leadership of the Project Committee, which is responsible for strategic foresight, and the Action Group, where representatives from different research bodies discuss concrete project plans.

   To expand the Project further, we are proceeding with establishment of a system that enables the participation of self-financed research bodies.

Figure 3

<Figure 3> Structure of the Project’s Promotion


Life Sciences Division, Research Promotion Bureau,
Ministry of Education, Culture, Sports, Science and Technology

 3-2-2, Kasumigaseki, Chiyoda-ku, Tokyo, 100-8959 JAPAN
 Phone:+81-3-5253-4111 Facsimile:+81-3-6734-4109

Genome Network Project Secretariat
 Mitsubishi Research Institute, Bldg., 2-3-6, Otemachi, Chiyoda-ku, Tokyo, 100-8141 JAPAN
 Phone:+81-3-3277-0503 Facsimile:+81-3-3277-4557

Action Group Secretariat, Genome Network Project
 RIKEN Yokohama Institute, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045 JAPAN
 Phone:+81-45-503-9424 Facsimile:+81-45-503-9421

 http://www.mext-life.jp/genome/index.html

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